by Deanna Nelson

GLP-1 receptor agonists (GLP-1 RAs), such as semaglutide and liraglutide, have become widely recognized for their effectiveness in supporting weight loss and blood sugar regulation. While these medications are undeniably pharmaceutical in nature—prescribed and monitored by healthcare professionals—they also open a broader conversation about how we care for our bodies during transformative health journeys.

These drugs work by mimicking a natural hormone that helps regulate appetite, insulin response and digestion. However, as with any medication, they may come with side effects—nausea, dehydration, constipation, muscle loss and changes in skin and bone health—that can disrupt the delicate balance of our body systems. This is where a holistic approach becomes essential.

Rather than simply managing symptoms with isolated solutions, holistic care addresses the body as an interconnected system—supporting emotional, physical and biochemical wellness through lifestyle, nutrition and mindfulness practices.

Here’s a brief comparison between common recommendations and more integrative options that nourish the body from the inside out:

One central theme in this approach is magnesium—a mineral that is involved in more than 300 biochemical reactions in the body. It supports digestive health, muscle recovery, nerve function, and even sleep quality, yet remains widely under-consumed. Supplementing with magnesium, particularly in the citrate or lactate form, and maintaining a balanced calcium-to-magnesium ratio (ideally 2:1) can enhance how our bodies tolerate and benefit from GLP-1 therapy.

It’s also important to remember that true wellness isn’t just about shedding pounds. It’s about building a lifestyle that supports sustained energy, balanced mood, strong bones, glowing skin and mental clarity. Integrating daily practices like yoga, clean eating, nature walks, hydration and mindful breathing helps restore equilibrium while enhancing the effectiveness of pharmacological treatments.

GLP-1 RAs may be a modern medical tool—but pairing them with ancient wisdom and whole-body care is the path to long-term transformation.

Deanna J. Nelson, Ph.D., and founder of ActiveSR supplements, is an internationally recognized leader in providing patented,
best-of-class nutritional and mineral supplements for people of all ages. For more information, email [email protected] or visit www.ActiveSR.com.